Granulomatous Osteonecrosis in Crohn’s Disease
A 25-year-old white woman was diagnosed with Crohn’s disease involving the small and large intestines. She had a complex clinical course that required treatment with multiple pharmacological agents, including intravenous, oral and rectal corticosteroids. She also received parenteral nutrition with l...
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/294195 |
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| _version_ | 1832554368030736384 |
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| author | Hugh J Freeman David Owen Mario Millan |
| author_facet | Hugh J Freeman David Owen Mario Millan |
| author_sort | Hugh J Freeman |
| collection | DOAJ |
| description | A 25-year-old white woman was diagnosed with Crohn’s disease involving the small and large intestines. She had a complex clinical course that required treatment with multiple pharmacological agents, including intravenous, oral and rectal corticosteroids. She also received parenteral nutrition with lipid emulsions. Finally, repeated intestinal resections and drainage of perianal abscesses were required. Her disease was complicated by gallstones, urolithiasis and hip pain. After osteonecrosis was diagnosed, joint replacements were performed. Review of the pathological sections from the resected hip, however, resulted in detection of granulomatous inflammation with multinucleated giant cells - the histological ’footprint’ of Crohn’s disease in the gastrointestinal tract. Because prior specialized perfusion fixation pathological studies of the intestine in Crohn’s disease have shown that granulomas are located in the walls of blood vessels, a possible mechanism for the pathogenesis of osteonecrosis in Crohn’s disease is chronic microvascular ischemia of bone. |
| format | Article |
| id | doaj-art-7d7dad9a6f2f47b0a2f22564fdab0dbe |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-7d7dad9a6f2f47b0a2f22564fdab0dbe2025-02-03T05:51:38ZengWileyCanadian Journal of Gastroenterology0835-79002000-01-01141195195410.1155/2000/294195Granulomatous Osteonecrosis in Crohn’s DiseaseHugh J Freeman0David Owen1Mario Millan2Department of Medicine (Gastroenterology) and Pathology, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine (Gastroenterology) and Pathology, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine (Gastroenterology), University of Alberta, Edmonton, Alberta, CanadaA 25-year-old white woman was diagnosed with Crohn’s disease involving the small and large intestines. She had a complex clinical course that required treatment with multiple pharmacological agents, including intravenous, oral and rectal corticosteroids. She also received parenteral nutrition with lipid emulsions. Finally, repeated intestinal resections and drainage of perianal abscesses were required. Her disease was complicated by gallstones, urolithiasis and hip pain. After osteonecrosis was diagnosed, joint replacements were performed. Review of the pathological sections from the resected hip, however, resulted in detection of granulomatous inflammation with multinucleated giant cells - the histological ’footprint’ of Crohn’s disease in the gastrointestinal tract. Because prior specialized perfusion fixation pathological studies of the intestine in Crohn’s disease have shown that granulomas are located in the walls of blood vessels, a possible mechanism for the pathogenesis of osteonecrosis in Crohn’s disease is chronic microvascular ischemia of bone.http://dx.doi.org/10.1155/2000/294195 |
| spellingShingle | Hugh J Freeman David Owen Mario Millan Granulomatous Osteonecrosis in Crohn’s Disease Canadian Journal of Gastroenterology |
| title | Granulomatous Osteonecrosis in Crohn’s Disease |
| title_full | Granulomatous Osteonecrosis in Crohn’s Disease |
| title_fullStr | Granulomatous Osteonecrosis in Crohn’s Disease |
| title_full_unstemmed | Granulomatous Osteonecrosis in Crohn’s Disease |
| title_short | Granulomatous Osteonecrosis in Crohn’s Disease |
| title_sort | granulomatous osteonecrosis in crohn s disease |
| url | http://dx.doi.org/10.1155/2000/294195 |
| work_keys_str_mv | AT hughjfreeman granulomatousosteonecrosisincrohnsdisease AT davidowen granulomatousosteonecrosisincrohnsdisease AT mariomillan granulomatousosteonecrosisincrohnsdisease |