Triptolide Causes Spermatogenic Disorders by Inducing Apoptosis in the Mitochondrial Pathway of Mouse Testicular Spermatocytes

Triptolide Causes Spermatogenic Disorders by Inducing Apoptosis in the Mitochondrial Pathway of Mouse Testicular Spermatocytes

Triptolide (TP) is a diterpenoid compound extracted from the traditional Chinese medicinal herb Tripterygium wilfordii. It has antitumor and anti-inflammatory effects and stimulates immunity. However, its serious side effects, especially reproductive toxicity, limit its clinical application. This st...

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Bibliographic Details
Main Authors: Jiantao Zhao, Maosheng Cao, Haisheng Yi, Guitian He, Tong Chen, Lingyun Liu, Kaimin Guo, Yin Cao, Chunjin Li, Xu Zhou, Boqi Zhang, Hongliang Wang
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Toxics
Subjects:
triptolide
testicular injury
spermatogenesis impairment
spermatocytes
mitochondria
Online Access:https://www.mdpi.com/2305-6304/12/12/896
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