In situ phenotypic and karyotypic co-detection of aneuploid TCs and TECs in cytological specimens with abnormal cervical screening results

In situ phenotypic and karyotypic co-detection of aneuploid TCs and TECs in cytological specimens with abnormal cervical screening results

Abstract Background To distinguish and co-detect aneuploid CD31− tumor cells (TCs) and CD31+ tumor endothelial cells (TECs) may have significant diagnostic values for cervical cancer screening. However, there are very few relevant studies. In the present study, a novel “immunofluorescence staining i...

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Bibliographic Details
Main Authors: Yanling Wang, Alexander Y. Lin, Daisy Dandan Wang, Peter Ping Lin, Xuexin Zhou, Yongbin Yang, Yaping Zhu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Cancer
Subjects:
Cervical cancer
Aneuploid TCs and TECs
iFISH tumor tissue biopsy
Chromosome 8
p16 and Ki67
HPV16/18
Online Access:https://doi.org/10.1186/s12885-025-14346-y
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https://doi.org/10.1186/s12885-025-14346-y

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