Genomic profiling of a collection of patient-derived xenografts and cell lines identified ixabepilone as an active drug against chemo-resistant osteosarcoma

Genomic profiling of a collection of patient-derived xenografts and cell lines identified ixabepilone as an active drug against chemo-resistant osteosarcoma

Abstract Background Osteosarcoma (OS) shows a multitude of genetic and chromosomal abnormalities together with large biological heterogeneity. These features limited the identification of novel drugs to treat patients with metastases and/or chemo-resistant tumors. The purpose of this study was to cr...

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Main Authors: Maria Cristina Manara, Francesca Bruzzese, Laura Formentini, Lorena Landuzzi, Laura Pazzaglia, Maria Antonella Laginestra, Marianna Carrabotta, Maria Serena Roca, Federica Iannelli, Laura Grumetti, Laura Addi, Alessandro Parra, Camilla Cristalli, Michela Pasello, Alberto Bavelloni, Francesca Carreras, Francesca Ruzzi, Giuseppe Bianchi, Marco Gambarotti, Alberto Righi, Alfredo Budillon, Pier-Luigi Lollini, Katia Scotlandi
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Osteosarcoma
Patient-Derived-Xenografts
Drug resistance
High-throughput drug screening
Ixabepilone
Online Access:https://doi.org/10.1186/s13046-025-03440-5
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https://doi.org/10.1186/s13046-025-03440-5

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