Sevoflurane exposure in early life: mitochondrial dysfunction and neurotoxicity in immature rat brains without long-term memory loss

Sevoflurane exposure in early life: mitochondrial dysfunction and neurotoxicity in immature rat brains without long-term memory loss

Abstract Neurotoxic effects of general anesthetics, particularly sevoflurane, on pediatric neurodevelopment are a global concern. This study investigated the molecular and metabolic impacts of repeated short exposures to sevoflurane in neonatal rats. Metabolomics analysis revealed significant change...

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Bibliographic Details
Main Authors: Lin Qiu, Hongwei Li, Bingbing Li, Joakim Ek, Xiaoli Zhang, Yiwen Chen, Zehua Shao, Jie Zhang, Jiaqiang Zhang, Hongqi Lin, Changlian Zhu, Yiran Xu, Xiaoyang Wang
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Sevoflurane
Metabolomics
Transcriptomics
Immature brain
Neurotoxicity
Online Access:https://doi.org/10.1038/s41598-024-79150-3
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https://doi.org/10.1038/s41598-024-79150-3

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