PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

Summary: Aerobic glycolysis, termed the Warburg effect, is one of the aberrant metabolic pathways in highly proliferating cells. Glycolysis provides glycolytic metabolites to support the generation of biomass, such as nucleotides, amino acids, and lipids. Research on the direct interactions between...

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Main Authors: Qingen Da, Yongfeng Cai, Qian Ma, Qiuhua Yang, Yapeng Cao, Yaqi Zhou, Dingwei Zhao, Zhiping Liu, Jiean Xu, Junming Quan, Liang Zhang, Rui Wang, Xuejun Jiang, Xiao Liu, Kunfu Ouyang, Zhen Han, Jikui Liu, Tao Wang, Chunxiang Zhang, Neal L. Weintraub, David J.R. Fulton, Jun Zhao, Mei Hong, Zigang Li, Yuqing Huo
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Metabolism
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008423
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