Cancer phylogenetic tree inference at scale from 1000s of single cell genomes

Cancer phylogenetic tree inference at scale from 1000s of single cell genomes

A new generation of scalable single cell whole genome sequencing (scWGS) methods allows unprecedented high resolution measurement of the evolutionary dynamics of cancer cell populations. Phylogenetic reconstruction is central to identifying sub-populations and distinguishing the mutational processes...

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Bibliographic Details
Main Authors: Salehi, Sohrab, Dorri, Fatemeh, Chern, Kevin, Kabeer, Farhia, Rusk, Nicole, Funnell, Tyler, Williams, Marc J., Lai, Daniel, Andronescu, Mirela, Campbell, Kieran R., McPherson, Andrew, Aparicio, Samuel, Roth, Andrew, Shah, Sohrab P., Bouchard-Côté, Alexandre
Format: Article
Language:English
Published: Peer Community In 2023-07-01
Series:Peer Community Journal
Subjects:
Phylogenetics, Cancer evolution, Bayesian statistics, MCMC, Copy number evolution, PDX, Triple negative breast cancer
Online Access:https://peercommunityjournal.org/articles/10.24072/pcjournal.292/
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https://peercommunityjournal.org/articles/10.24072/pcjournal.292/

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