Causes of resistance to PARP inhibitors and ways to overcome it. Case report of aggressive <i>BRCA</i>-related breast cancer

Causes of resistance to PARP inhibitors and ways to overcome it. Case report of aggressive <i>BRCA</i>-related breast cancer

PARP inhibitors. However, in clinical practice, despite the proven antitumor efficacy of drugs, acquired resistance to PARP inhibitors leads to difficulties in selecting further therapy due unknown resistance mechanisms and absence of algorithm of action. Despite the various mechanisms of resistance...

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Bibliographic Details
Main Authors: A. I. Stukan, A. Yu. Goryainova, S. V. Sharov, O. A. Goncharova, Z. K. Khachmamuk, V. V. Durov
Format: Article
Language:Russian
Published: ABV-press 2022-05-01
Series:Опухоли женской репродуктивной системы
Subjects:
breast cancer
brca mutation
resistance to papr inhibitors
olaparib
Online Access:https://ojrs.abvpress.ru/ojrs/article/view/934
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