Mesenchymal stem cell-derived exosome subpopulations remained consistent for 28 culture days, displaying therapeutic effects in a silicosis mouse model

Mesenchymal stem cell-derived exosome subpopulations remained consistent for 28 culture days, displaying therapeutic effects in a silicosis mouse model

IntroductionThe clinical translation of mesenchymal stem cell-derived exosome faces critical challenges in scalable production, subpopulation stability, and therapeutic route optimization. This study systematically addresses these barriers to advance exosome-based therapies.MethodsWe established a 2...

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Main Authors: Lina Zhang, Jing Jin, Liguang Sun, Gang Hou, Mingming Deng, Yiding Bian, Jianming Liu, Wei Cheng, Shaoliang Xing, Wenjia Wang, Xin Dong, Qingjie Fan, Lei Gao, Xinhua Lei, Yongli Bao, Yongguang Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mesenchymal stem cells exosomes
exosome subpopulation heterogeneity
scalable production
biomanufacturing workflow
natural exosome therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1550447/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1550447/full

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