NTN-1 attenuates amyloid-β-mediated microglial neuroinflammation and memory impairment via the NF-κB pathway and NLRP3 inflammasome in a rat model of Alzheimer's disease

NTN-1 attenuates amyloid-β-mediated microglial neuroinflammation and memory impairment via the NF-κB pathway and NLRP3 inflammasome in a rat model of Alzheimer's disease

IntroductionNeuroinflammation driven by microglial activation represents a pivotal pathological mechanism underlying brain injury in Alzheimer's disease (AD), with NLRP3 inflammasome activation being a hallmark feature of this process. Netrin-1 (NTN-1) was recently shown to have potent anti-inf...

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Bibliographic Details
Main Authors: Tianhang Wang, Yanchen Liu, Yidan Lu, Lijun Chi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
netrin-1
microglia
neuroinflammation
NLRP3 inflammasome
NF-κB
Alzheimer's disease (AD)
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1516399/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1516399/full

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