Assessing in vitro stability of remdesivir (GS-5734) and conversion to GS-441524 in feline plasma and whole blood

Assessing in vitro stability of remdesivir (GS-5734) and conversion to GS-441524 in feline plasma and whole blood

Feline infectious peritonitis (FIP) is a potentially fatal coronavirus-driven disease of cats. Treatment with nucleoside analogue GS-441524 and or prodrug remdesivir (RDV) have produced remission in both experimentally induced and naturally occurring FIP, yet information regarding metabolism of RDV...

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Bibliographic Details
Main Authors: Sally J. Coggins, Benjamin Kimble, Richard Malik, Mary F. Thompson, Jacqueline M. Norris, Merran Govendir
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Veterinary Quarterly
Subjects:
Feline infectious peritonitis
FIP
GS-441524
remdesivir
GS-5734
feline microsome
Online Access:https://www.tandfonline.com/doi/10.1080/01652176.2024.2305731
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https://www.tandfonline.com/doi/10.1080/01652176.2024.2305731

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