An mRNA vaccine encoding the SARS-CoV-2 Omicron XBB.1.5 receptor-binding domain protects mice from the JN.1 variantResearch in context

An mRNA vaccine encoding the SARS-CoV-2 Omicron XBB.1.5 receptor-binding domain protects mice from the JN.1 variantResearch in context

Summary: Background: The SARS-CoV-2 Omicron BA.2.86 variant and its descendant lineages, including JN.1, are rapidly spreading globally. We developed mRNA encoding the SARS-CoV-2 RBD derived from XBB.1.5 (XBB.1.5-type LNP-mRNA-RBD), in line with WHO recommendations. Many individuals have acquired i...

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Main Authors: Ryuta Uraki, Maki Kiso, Mutsumi Ito, Seiya Yamayoshi, Peter Halfmann, Shilpi Jain, Mehul S. Suthar, Tiago J.S. Lopes, Nao Jounai, Kazuki Miyaji, Fumihiko Takeshita, Yoshihiro Kawaoka
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:EBioMedicine
Subjects:
SARS-CoV-2
LNP-mRNA-RBD
Omicron JN.1 variant
Mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002385
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http://www.sciencedirect.com/science/article/pii/S2352396425002385

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