Association analysis between polygenic risk scores and traits: practical guidelines and tutorial with an illustrative data set of schizophrenia

Association analysis between polygenic risk scores and traits: practical guidelines and tutorial with an illustrative data set of schizophrenia

Most methodological Polygenic Risk Score (PRS)-related papers explain the laborious process of computing the PRS in great depth. Afterwards, as a last step, it is generally described that to test a possible association between a PRS and a trait of interest, an analysis through regression models (lin...

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Bibliographic Details
Main Authors: Itziar Irigoien, Patricia Mas-Bermejo, Sergi Papiol, Neus Barrantes-Vidal, Araceli Rosa, Concepción Arenas
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Psychiatry
Subjects:
polygenic risk score
statistical analysis
covariates
schizophrenia
psychotic-like experiences
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1621972/full
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https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1621972/full

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