Performance of new pp65-IGRA for the quantification of HCMV-specific CD4+ T-cell response in healthy subjects and in solid organ transplant recipients

Performance of new pp65-IGRA for the quantification of HCMV-specific CD4+ T-cell response in healthy subjects and in solid organ transplant recipients

Immune control of human cytomegalovirus (HCMV) replication is critical in bone marrow and solid organ transplant recipients, where uncontrolled replication can lead to high mortality. Current commercial immune monitoring tools have several limitations, such as a lack of appropriate test cutoff value...

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Bibliographic Details
Main Authors: Dalila Mele, Federica Zavaglio, Federica Bergami, Marilena Gregorini, Domenica Federica Briganti, Carlo Pellegrini, Giuditta Comolli, Irene Cassaniti, Daniele Lilleri, Fausto Baldanti
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
HCMV
IFN-γ
IGRA
pp65
HCMV-specific T cell response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1553305/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1553305/full

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