Harnessing Raman Spectroscopy for Enhanced Bioprocess Monitoring: Predictive CO<sub>2</sub> Analysis and Robust pH Determination in Bioreactor Off-Gas Stream

Harnessing Raman Spectroscopy for Enhanced Bioprocess Monitoring: Predictive CO<sub>2</sub> Analysis and Robust pH Determination in Bioreactor Off-Gas Stream

The accurate measurement of CO<sub>2</sub> concentration in fermentation off-gas is crucial for monitoring and optimizing bioprocesses, particularly in mammalian cell cultures. In this study, we successfully utilized Raman off-gas spectroscopy to achieve time-resolved prediction of CO<...

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Bibliographic Details
Main Authors:	Tobias Wallocha, Michaela Poth
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Series:	Fermentation
Subjects:	Raman spectroscopy Raman off-gas analysis off-gas analytic CO<sub>2</sub> in bioprocesses pH pH calculation via off-gas CO<sub>2</sub>
Online Access:	https://www.mdpi.com/2311-5637/11/6/317
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