Alpha-estradiol and (R)-(−)-ibuprofen inhibit gastric cancer progression via GLI1 G-quadruplex

Alpha-estradiol and (R)-(−)-ibuprofen inhibit gastric cancer progression via GLI1 G-quadruplex

BackgroundThe transcription factor GLI1, aberrantly activated in gastric cancer, drives tumor progression, yet no approved inhibitors currently target this molecule. G-quadruplex (G4) motifs in promoter regions have emerged as promising therapeutic targets. This study explores G4 stabilization in th...

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Bibliographic Details
Main Authors: Qiang Li, Pan Pan, Qingqing Xian, Jingtan Li, Jingting Wang, Jiaying Cai, Jing Wang, Yanfei Jia, Haiji Sun, Lulu Zhang, Xiaoli Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
G-quadruplex
GLI1
alpha-estradiol
(R)-(−)-ibuprofen
PRKACB
gastric cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1492694/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1492694/full

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