Sequential versus massively parallel strategies for molecular characterization of non-small cell lung cancer samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration

Sequential versus massively parallel strategies for molecular characterization of non-small cell lung cancer samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration

ABSTRACT Objectives: The advent of massively parallel next-generation sequencing (MP-NGS) offers potential advantages over sequential molecular profiling (SMP) in the management of non-small cell lung cancer (NSCLC). This study compares the two methodologies using samples obtained through endobronc...

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Bibliographic Details
Main Authors: Luís Vaz Rodrigues, Marta Viegas, Ana Filipa Ladeirinha, Ana Alarcão, Luis Taborda-Barata, Rosa Cordovilla, Vitor Sousa
Format: Article
Language:English
Published: Sociedade Brasileira de Pneumologia e Tisiologia 2025-08-01
Series:Jornal Brasileiro de Pneumologia
Subjects:
Non-Small Cell Lung Cancer
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration
Sequential Molecular Profiling
Massively Parallel Next-Generation Sequencing
Actionable Mutations
Personalized Therapy
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132025000400600&lng=en&tlng=en
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