Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet
The high consumption of olive tree products in the Mediterranean diet has been associated with a lower incidence of metabolic disorders and cardiovascular diseases. In particular, the protective effects of olive oil have been attributed to the presence of polyphenols such as oleuropein (Ole) and its...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/431453 |
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| author | Saverio Massimo Lepore Valeria Maria Morittu Marilena Celano Francesca Trimboli Manuela Oliverio Antonio Procopio Carla Di Loreto Giuseppe Damante Domenico Britti Stefania Bulotta Diego Russo |
| author_facet | Saverio Massimo Lepore Valeria Maria Morittu Marilena Celano Francesca Trimboli Manuela Oliverio Antonio Procopio Carla Di Loreto Giuseppe Damante Domenico Britti Stefania Bulotta Diego Russo |
| author_sort | Saverio Massimo Lepore |
| collection | DOAJ |
| description | The high consumption of olive tree products in the Mediterranean diet has been associated with a lower incidence of metabolic disorders and cardiovascular diseases. In particular, the protective effects of olive oil have been attributed to the presence of polyphenols such as oleuropein (Ole) and its derivatives. We have synthesized a peracetylated derivative of Ole (Ac-Ole) which has shown in vitro antioxidant and growth-inhibitory activity higher than the natural molecule. In this study, male C57BL/6JOlaHsd mice were fed with a standard (std), cafeteria (caf) diet, and caf diet supplemented with Ole (0.037 mmol/kg/day) and Ac-Ole (0.025 mmol/kg/day) for 15 weeks. We observed a significant reduction in the caf diet-induced body weight gain and increase of abdominal adipose tissue. Also, Ole and Ac-Ole prevented the development of hepatic steatosis. Finally, Ole and Ac-Ole determined a lower increase of HDL and LDL-cholesterol levels and corrected caf diet-induced elevation of plasma glucose concentrations by improving insulin sensitivity. The observed beneficial properties of Ole and Ac-Ole make these compounds and in particular Ac-Ole promising candidates for a potential pharmaceutic use in metabolic disorders. |
| format | Article |
| id | doaj-art-7cc7575486d74cceb8bd9eea83154c87 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-7cc7575486d74cceb8bd9eea83154c872025-02-03T00:59:34ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/431453431453Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria DietSaverio Massimo Lepore0Valeria Maria Morittu1Marilena Celano2Francesca Trimboli3Manuela Oliverio4Antonio Procopio5Carla Di Loreto6Giuseppe Damante7Domenico Britti8Stefania Bulotta9Diego Russo10Department of Health Sciences, University “Magna Graecia” of Catanzaro, Campus “S. Venuta”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, Campus “S. Venuta”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, Campus “S. Venuta”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, Campus “S. Venuta”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, Campus “S. Venuta”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, Campus “S. Venuta”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Medical and Biological Sciences, University of Udine, Piazzale Kolbe 4, 33100 Udine, ItalyDepartment of Medical and Biological Sciences, University of Udine, Piazzale Kolbe 4, 33100 Udine, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, Campus “S. Venuta”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, Campus “S. Venuta”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, Campus “S. Venuta”, Viale Europa, Germaneto, 88100 Catanzaro, ItalyThe high consumption of olive tree products in the Mediterranean diet has been associated with a lower incidence of metabolic disorders and cardiovascular diseases. In particular, the protective effects of olive oil have been attributed to the presence of polyphenols such as oleuropein (Ole) and its derivatives. We have synthesized a peracetylated derivative of Ole (Ac-Ole) which has shown in vitro antioxidant and growth-inhibitory activity higher than the natural molecule. In this study, male C57BL/6JOlaHsd mice were fed with a standard (std), cafeteria (caf) diet, and caf diet supplemented with Ole (0.037 mmol/kg/day) and Ac-Ole (0.025 mmol/kg/day) for 15 weeks. We observed a significant reduction in the caf diet-induced body weight gain and increase of abdominal adipose tissue. Also, Ole and Ac-Ole prevented the development of hepatic steatosis. Finally, Ole and Ac-Ole determined a lower increase of HDL and LDL-cholesterol levels and corrected caf diet-induced elevation of plasma glucose concentrations by improving insulin sensitivity. The observed beneficial properties of Ole and Ac-Ole make these compounds and in particular Ac-Ole promising candidates for a potential pharmaceutic use in metabolic disorders.http://dx.doi.org/10.1155/2015/431453 |
| spellingShingle | Saverio Massimo Lepore Valeria Maria Morittu Marilena Celano Francesca Trimboli Manuela Oliverio Antonio Procopio Carla Di Loreto Giuseppe Damante Domenico Britti Stefania Bulotta Diego Russo Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet International Journal of Endocrinology |
| title | Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet |
| title_full | Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet |
| title_fullStr | Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet |
| title_full_unstemmed | Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet |
| title_short | Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet |
| title_sort | oral administration of oleuropein and its semisynthetic peracetylated derivative prevents hepatic steatosis hyperinsulinemia and weight gain in mice fed with high fat cafeteria diet |
| url | http://dx.doi.org/10.1155/2015/431453 |
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