Formation of dimers in refolding of recombinant human interferon-γ by ion-exchange chromatography

The refolding process was performed by gradually decreasing the concentration of urea in the buffer after the denatured rhIFN-γ proteins had been bound onto the ion-exchange gel SP Sepharose Fast Flow. Results showed that the denatured rhIFN-γ was refolded efficiently by ion-exchange chromatography...

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Bibliographic Details
Main Authors: JIN Ting, GUAN Yi-xin, YAO Shan-jing
Format: Article
Language:English
Published: Zhejiang University Press 2006-01-01
Series:浙江大学学报. 农业与生命科学版
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Online Access:https://www.academax.com/doi/10.3785/1008-9209.2006.01.0101
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