LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease.

LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease.

<h4>Background & aims</h4>Non-alcoholic steatohepatitis (NASH) involves steatosis combined with inflammation, which can progress into fibrosis and cirrhosis. Exploring the molecular mechanisms of NASH is highly dependent on the availability of animal models. Currently, the most commo...

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Main Authors: Veerle Bieghs, Patrick J Van Gorp, Kristiaan Wouters, Tim Hendrikx, Marion J Gijbels, Marc van Bilsen, Jaap Bakker, Christoph J Binder, Dieter Lütjohann, Bart Staels, Marten H Hofker, Ronit Shiri-Sverdlov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030668&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030668&type=printable

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