Progression to fibrosis and hepatocellular carcinoma in DEN CCl4 liver mice, is associated with macrophage and striking regulatory T cells infiltration

Progression to fibrosis and hepatocellular carcinoma in DEN CCl4 liver mice, is associated with macrophage and striking regulatory T cells infiltration

Background and aimHepatocellular carcinoma (HCC) is a classic inflammation related cancer with most cases arising from chronic liver disease (CLD). This study investigates immune dysregulation that occurs during the progression of CLD to HCC by delineating changes in immune cell composition and dist...

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Bibliographic Details
Main Authors: Ananya Ajith, Jonathan Evraerts, Caroline Bouzin, Davide Brusa, Makram Merimi, Mehdi Najar, Françoise Smets, Etienne Sokal, Mustapha Najimi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
liver
liver fibrosis
hepatocellular carcinoma
immune cells
multiplex immunofluorescence
flow cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1601215/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1601215/full

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