A dietary combination of red yeast rice, phytosterol ester and lycopene ameliorates hypercholesterolemia by regulating gut microbiota and activating hepatic FXR-LDLR/ABCG pathway in mice

A dietary combination of red yeast rice, phytosterol ester and lycopene ameliorates hypercholesterolemia by regulating gut microbiota and activating hepatic FXR-LDLR/ABCG pathway in mice

BackgroundExcessive nutrition intake is a well-established contributor to obesity and hypercholesterolemia, both of which pose substantial risks to cardiovascular health. Statins, which are widely prescribed for managing serum cholesterol levels, are sometimes discontinued owing to adverse reactions...

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Main Authors: Jingxian Xu, Xin Huang, Fei Pei, Yuzhu Chen, Cunzheng Zhang, Lingling Zhao, Hua Zhang, Jindong Zhang, Liping Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Microbiology
Subjects:
red yeast rice
hypercholesterolemia
gut microbiota
bile acid metabolism
FXR-LDLR/ABCG5/8 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1622818/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1622818/full

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