Disrupting SARS-CoV-2 Spike–ACE2 Interactions via Glycosaminoglycans in a Pseudoviral Study of Heparan Sulfate and Enoxaparin

Disrupting SARS-CoV-2 Spike–ACE2 Interactions via Glycosaminoglycans in a Pseudoviral Study of Heparan Sulfate and Enoxaparin

Background: The COVID-19 (coronavirus disease 19) pandemic has underscored the urgent need for effective antiviral agents targeting viral entry mechanisms. This study investigated the inhibitory effects of heparan sulfate (HS) and enoxaparin (EX) on the interaction between the severe acute respirato...

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Bibliographic Details
Main Authors: Virginia Fuochi, Salvatore Furnari, Filippo Drago, Pio Maria Furneri
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
SARS-CoV-2
spike protein
ACE2 receptor
heparan sulfate
enoxaparin
viral entry inhibition
Online Access:https://www.mdpi.com/2218-273X/15/7/931
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