CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma

CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma

Abstract Boosting antitumor immunity has emerged as a powerful strategy in cancer treatment. While releasing T‐cell brakes has received most attention, tumor recognition by T cells is a pre‐requisite. Radiotherapy and certain cytotoxic drugs induce the release of damage‐associated molecular patterns...

Full description

Saved in:
Bibliographic Details
Main Authors: Rosanna Mezzapelle, Francesco De Marchis, Chiara Passera, Manuela Leo, Francesca Brambilla, Federica Colombo, Maura Casalgrandi, Alessandro Preti, Samuel Zambrano, Patrizia Castellani, Riccardo Ertassi, Marco Silingardi, Francesca Caprioglio, Veronica Basso, Renzo Boldorini, Angelo Carretta, Francesca Sanvito, Ottavio Rena, Anna Rubartelli, Lina Sabatino, Anna Mondino, Massimo P Crippa, Vittorio Colantuoni, Marco E Bianchi
Format: Article
Language:English
Published: Springer Nature 2021-05-01
Series:EMBO Molecular Medicine
Subjects:
CD47
CXCR4
HMGB1
immunogenic cell death
mesothelioma
Online Access:https://doi.org/10.15252/emmm.202012344
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.15252/emmm.202012344

Similar Items