Iron responsive elements mRNA regulate Alzheimer’s amyloid precursor protein translation through iron sensing
Iron responsive element (IREs) mRNA and iron regulatory proteins (IRPs) regulate iron homeostasis. 5′-untranslated region motifs of APP IREs fold into RNA stem loops bind to IRP to control translation. Through the 5’-UTR APP IREs, iron overload accelerated the translation of the Alzheimer’s amyloid...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1483913/full |
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