TRBP modulates RLR signaling by inhibiting PKR-mediated antiviral stress granule formation

TRBP modulates RLR signaling by inhibiting PKR-mediated antiviral stress granule formation

Abstract Stress granules (SGs) are dense aggregates of RNA and proteins that form in response to various cellular stresses. Virus-induced SGs, known as antiviral SGs (avSGs), play a crucial role in regulating retinoic acid-inducible gene I-like receptors (RLRs)-mediated antiviral innate immunity. Ho...

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Main Authors: Koji Onomoto, Monami Sakai, Miyu Watanabe, Akira Fukao, Yurika Sakamura, Mai Miyao, Takumi Tomohiro, Akio Yamashita, Toshinobu Fujiwara, Tomoko Takahashi, Kumiko Ui-Tei, Mitsutoshi Yoneyama
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Antiviral innate immunity
RLR
Stress granule
IFN
TRBP
Online Access:https://doi.org/10.1038/s41598-025-07121-3
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https://doi.org/10.1038/s41598-025-07121-3

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