A nonclassical pathway of β-hematin crystal nucleation enables its suppression by antimalarials

Abstract Organic biocrystals support essential functions or drive pathologies in numerous living organisms. Here we focus on the nucleation of hematin crystals, which form in malaria parasites as a part of their heme detoxification pathway. Suppression of hematin crystal nucleation has proven the mo...

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Bibliographic Details
Main Authors: Wenchuan Ma, Lakshmanji Verma, Huan-Jui Lee, Weichun Pan, Michael B. Sherman, David J. Sullivan, Jeffrey D. Rimer, Jeremy C. Palmer, Peter G. Vekilov
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01612-0
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