Novel hypoxia-induced HIF-1αactivation in asthma pathogenesis

Novel hypoxia-induced HIF-1αactivation in asthma pathogenesis

Abstract Background Asthma’s complexity, marked by airway inflammation and remodeling, is influenced by hypoxic conditions. This study focuses on the role of Hypoxia-Inducible Factor-1 Alpha (HIF-1α) and P53 ubiquitination in asthma exacerbation. Methods High-throughput sequencing and bioinformatics...

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Bibliographic Details
Main Authors: Mengzhi Wan, Qi Yu, Fei Xu, Lu Xia You, Xiao Liang, Kang kang Ren, Jing Zhou
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Respiratory Research
Subjects:
Asthma
Hypoxia
HIF-1α
P53 ubiquitination
Airway Remodeling
Online Access:https://doi.org/10.1186/s12931-024-02869-0
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https://doi.org/10.1186/s12931-024-02869-0

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