Deletion of the E3 ubiquitin ligase LRSAM1 fosters intracellular Staphylococcus aureus survival

Deletion of the E3 ubiquitin ligase LRSAM1 fosters intracellular Staphylococcus aureus survival

BackgroundIntracellular invasion and persistence of Staphylococcus aureus can lead to chronic infection and is an effective strategy for the pathogen to evade the host immune response and antibiotic therapy. Selective ubiquitination of bacterial surfaces via E3 ubiquitin ligases is a mechanism by wh...

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Bibliographic Details
Main Authors: Ole Plöhn, Abhishek Kumar Singh, Clara Greger, Hannes Wolfgramm, Madina Baglanova, Kristin Surmann, Uwe Völker, Barbara M. Bröker, Karsten Becker, Ulrike Seifert, Clemens Cammann
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
S. aureus
ubiquitin
selective autophagy
LRSAM1
intracellular bacteria
E3 ligase
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1597830/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1597830/full

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