TLR4 identified as a major depressive disorder gene signature mediating effects through multiple immune cells

Abstract The pathogenesis of major depressive disorder (MDD) is currently unclear and lacks objective diagnostic criteria. The complexity and heterogeneity of MDD also limit precise treatment. Using bioinformatics methods, we identified 18 gene signatures of MDD from the GSE98793 dataset, and valida...

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Bibliographic Details
Main Authors: Jiayi Wei, Lei Tang, Sijian Wang, Xiang Yuan, Rong Liao, Yuling Wu, NanQi Huang, Hangchi Liu, Hanyan Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-95663-x
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