Locomotor activity depends on β-arrestin recruitment by the dopamine D1 receptor in the striatal D1-D3 receptor heteromer

Locomotor activity depends on β-arrestin recruitment by the dopamine D1 receptor in the striatal D1-D3 receptor heteromer

Several dopaminergic compounds, including the clinically used pramipexole, are labelled as preferential dopamine D3 receptor (D3R) agonists based on their moderately higher affinity for the D3R versus other D2-like receptor subtypes. In rodents, these compounds typically produce locomotor depression...

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Main Authors: Alexandra H. Evans, Marc Ciruela-Jardí, William Rea, Bradley M. Keegan, Marjorie R. Levinstein, Alessandro Bonifazi, Jianjing Cao, Shelley N. Jackson, Lei Shi, Nil Casajuana-Martin, Ning-Sheng Cai, Vicent Casadó, Christopher J. Earley, Amy H. Newman, Michael Michaelides, Leonardo Pardo, Estefanía Moreno, Sergi Ferré
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Pharmacological Research
Subjects:
Dopamine D1 receptor
Dopamine D3 receptor
Heteromers
Striatum
β-arrestin
Locomotor activity
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825002518
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