MUC18-Directed chimeric antigen receptor T cells for the treatment of mucosal melanoma

MUC18-Directed chimeric antigen receptor T cells for the treatment of mucosal melanoma

Abstract Purpose Mucosal melanoma, a highly aggressive form of skin cancer, remains challenging to manage due to the lack of effective therapies. Mucin 18 (MUC18) is overexpressed in both primary and metastatic lesions of melanoma but rarely in normal tissues. The expression profile makes MUC18 a po...

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Main Authors: Fenghao Zhang, Haizhen Du, Kaiping Liu, Qian Guo, Mengmeng Liang, Jing Shi, Shi Feng, Ting He, Xin-an Lu, Yanfang Tang, Lihua Wang, Qiaozhen Li, Xun Meng, Shu-Hui Liu, Yanping Ding, Yan Kong
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
MUC18
CAR-T
Mucosal melanoma
Preclinical efficacy
Online Access:https://doi.org/10.1186/s12967-025-06365-x
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https://doi.org/10.1186/s12967-025-06365-x

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