Egg exosome miR-145-5p decreases mitochondrial ROS to protect chicken embryo hepatocytes against apoptosis through targeting MAPK10

Egg exosome miR-145-5p decreases mitochondrial ROS to protect chicken embryo hepatocytes against apoptosis through targeting MAPK10

Abstract Background Higher embryonic mortality, especially in aged breeding hens, is associated with insufficient hepatic functionality in maintaining redox homeostasis. Our previous study demonstrated that egg exosome-derived miRNAs may play a key role in modulating embryonic oxidation-reduction pr...

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Bibliographic Details
Main Authors: Fengdong Zhang, Yongchang Han, Fan Li, Boya Guo, Jian Chen, Wenchuan Zhou, Pan Xiao, Hui Ma, Yongyan Jin, Jia Feng, Yuna Min
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Animal Science and Biotechnology
Subjects:
Aged breeding hen
Apoptosis
Exosome
Hatchability
MiR-145-5p
Online Access:https://doi.org/10.1186/s40104-025-01203-y
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https://doi.org/10.1186/s40104-025-01203-y

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