Effects of metformin supplementation in high-carbohydrate diets on growth performance, glucose metabolism, intestinal flora, and PI3K/AKT signaling pathway of hybrid grouper (Epinephelus fuscoguttatus♀×Epinephelus lanceolatu♂)

Effects of metformin supplementation in high-carbohydrate diets on growth performance, glucose metabolism, intestinal flora, and PI3K/AKT signaling pathway of hybrid grouper (Epinephelus fuscoguttatus♀×Epinephelus lanceolatu♂)

Metformin, or 1,1-dimethylbiguanide, is a hypoglycemic drug that lowers blood glucose by reducing glycogen synthesis and increasing glucose uptake in peripheral tissues. Six diets with iso-nitrogenous and iso-lipid compositions were prepared, including a positive control (20 % carbohydrate, PC) and...

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Main Authors: Jiasheng Wen, Qintong Yu, Ling Pan, Hongyu Liu, Beiping Tan, Xiaohui Dong, Shuyan Chi, Qihui Yang, Shuang Zhang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Aquaculture Reports
Subjects:
Metformin
Glucose metabolism
Intestinal flora
PI3K/AKT
Online Access:http://www.sciencedirect.com/science/article/pii/S2352513424005969
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