Synthetic data as external control arms in scarce single-arm clinical trials.

An external control arm based on health registry data can serve as an alternative comparator in single-arm drug development studies that lack a benchmark for comparison to the experimental treatment. However, accessing such observational healthcare data involves a lengthy and intricate application p...

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Bibliographic Details
Main Authors: Severin Elvatun, Daan Knoors, Simon Brant, Christian Jonasson, Jan F Nygård
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLOS Digital Health
Online Access:https://doi.org/10.1371/journal.pdig.0000581
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