Modulation of retinal inflammation delays degeneration in a mouse model of geographic atrophy

Modulation of retinal inflammation delays degeneration in a mouse model of geographic atrophy

Abstract Geographic atrophy, the advanced form of age-related macular degeneration (AMD), is associated with increased oxidative stress and chronic inflammation. Pro-inflammatory genes, like TNF-α and IL-1β, are under the regulation of the transcription factor p65/RelA. We have previously shown that...

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Bibliographic Details
Main Authors: Raela B. Ridley, Brianna M. Tischner, Jieun Lee, Erin Walsh, Michael T. Massengill, Alfred S. Lewin, Cristhian J. Ildefonso
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Age-related macular degeneration
Myxoma virus
Retinal inflammation
NF-kB
Online Access:https://doi.org/10.1038/s41598-025-15891-z
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https://doi.org/10.1038/s41598-025-15891-z

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