Chidamide and cytarabine synergistically treat acute myeloid leukemia: inhibiting ribosome biogenesis via the MYC-RRP9 pathway

Chidamide and cytarabine synergistically treat acute myeloid leukemia: inhibiting ribosome biogenesis via the MYC-RRP9 pathway

Abstract This study explores innovative therapeutic approaches for acute myeloid leukemia by examining the synergistic effects of the histone deacetylase inhibitor chidamide in combination with cytarabine. In both in vitro and in vivo models, the drug combination demonstrated significant synergism i...

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Main Authors: Qing Li, Fangfang Wang, Xinrong Xiang, Lei Zhao, Xuefeng Li, Ying Qu, Jingcao Huang, Yunfan Yang, Yang Dai, Xiao Shuai, Jiazhuo Liu, Jie Huang, Yu Liu, Yu Wu
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07928-y
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https://doi.org/10.1038/s41419-025-07928-y

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