Obesity enriches for tumor protective microbial metabolites and treatment refractory cells to confer therapy resistance in PDAC

Obesity enriches for tumor protective microbial metabolites and treatment refractory cells to confer therapy resistance in PDAC

Obesity causes chronic inflammation and changes in gut microbiome. However, how this contributes to poor survival and therapy resistance in patients with pancreatic cancer remain undetermined. Our current study shows that high fat diet-fed obese pancreatic tumor bearing mice do not respond to standa...

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Main Authors: Kousik Kesh, Roberto Mendez, Beatriz Mateo-Victoriano, Vanessa T Garrido, Brittany Durden, Vineet K Gupta, Alfredo Oliveras Reyes, Nipun Merchant, Jashodeep Datta, Santanu Banerjee, Sulagna Banerjee
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Gut Microbes
Subjects:
Pancreatic cancer
chemoresistance
gut microbiome
obesity
queuosine S-adenosyl methionine
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2022.2096328
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https://www.tandfonline.com/doi/10.1080/19490976.2022.2096328

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