Development of novel neutralizing single-chain fragment variable antibodies against S100A8

Development of novel neutralizing single-chain fragment variable antibodies against S100A8

Abstract S100A8 plays a critical role in the pathogenesis of several inflammatory diseases and multiple types of cancer. Therefore, targeting the S100A8 function may alleviate the pathogenic process in various diseases. Here, specific single-chain variable fragment (scFv) antibodies targeting recomb...

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Main Authors: Hamideh Raeisi, Masoumeh Azimirad, Alexandru Schiopu, Amir-Hassan Zarnani, Hamid Asadzadeh Aghdaei, Elham Abdemohamadi, Mohammad Reza Zali, Abbas Yadegar
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
S100A8
scFv
Phage display
Inflammation
Apoptosis
Therapeutics
Online Access:https://doi.org/10.1038/s41598-025-96211-3
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https://doi.org/10.1038/s41598-025-96211-3

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