Immune and vascular modulation by HERVs: the role of CXCR1 and IL18RAP in dengue severity progression

Immune and vascular modulation by HERVs: the role of CXCR1 and IL18RAP in dengue severity progression

IntroductionHuman Endogenous Retroviruses (HERVs), which can be activated by viral infections, have complex roles in gene regulation and immune modulation. However, their contribution to disease progression is not yet fully understood. Dengue fever ranges from mild symptoms to severe cases character...

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Main Authors: Cristina Santos Ferreira, Alan Tardin Da Silva, Otávio José Bernandes Brustolini, Beatriz Rodrigues Pellegrina Soares, Erika Regina Manuli, Mariana Severo Ramundo, Glaucia Paranhos-Baccala, Ester Cerdeira Sabino, Ana Tereza Ribeiro Vasconcelos
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
dengue infection
endogenous retroviruses
severity progression of dengue
vascular leakage
HERV
RNA-seq -RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557588/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557588/full

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