Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.

Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.

<h4>Background</h4>Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by parkinsonism, cerebellar ataxia and autonomic dysfunction. Pathogenic mechanisms remain obscure but the neuropathological hallmark is the presence of alpha-synuclein-immunoreacti...

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Main Authors: Ammar Al-Chalabi, Alexandra Dürr, Nicholas W Wood, Michael H Parkinson, Agnes Camuzat, Jean-Sébastien Hulot, Karen E Morrison, Alan Renton, Sigurd D Sussmuth, Bernhard G Landwehrmeyer, Albert Ludolph, Yves Agid, Alexis Brice, P Nigel Leigh, Gilbert Bensimon, NNIPPS Genetic Study Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007114&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007114&type=printable

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