Mice with chimeric livers are an improved model for human lipoprotein metabolism.

Mice with chimeric livers are an improved model for human lipoprotein metabolism.

<h4>Objective</h4>Rodents are poor model for human hyperlipidemias because total cholesterol and low density lipoprotein levels are very low on a normal diet. Lipoprotein metabolism is primarily regulated by hepatocytes and we therefore assessed whether chimeric mice extensively repopula...

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Main Authors: Ewa C S Ellis, Willscott Edward Naugler, Paolo Parini, Lisa-Mari Mörk, Carl Jorns, Helen Zemack, Anita Lövgren Sandblom, Ingemar Björkhem, Bo-Göran Ericzon, Elizabeth M Wilson, Stephen C Strom, Markus Grompe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0078550
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https://doi.org/10.1371/journal.pone.0078550

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