Paeoniflorin Alleviates Lipopolysaccharide-Induced Neuroinflammation and Depression Through the Keap1/Nrf2/HO-1 Signaling Pathway

Paeoniflorin Alleviates Lipopolysaccharide-Induced Neuroinflammation and Depression Through the Keap1/Nrf2/HO-1 Signaling Pathway

Depression is associated with bidirectional interactions between inflammatory responses and behavioral dysfunction. Paeoniflorin (PF), a monoterpene glycoside derived from <i>Paeonia lactiflora</i>, exhibits potent anti-inflammatory properties. This study investigates the therapeutic eff...

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Bibliographic Details
Main Authors: Zhuoyue Hu, Xing Wang, Tian Shi, Lei Yang, Boxi Zhang, Bo Shang, Ruizhi He, Shichen Yi, Jiao He, Jing Hu, Yanjun Cao
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Antioxidants
Subjects:
paeoniflorin
depression
lipopolysaccharide
neuroinflammation
Nrf2/HO-1
Online Access:https://www.mdpi.com/2076-3921/14/5/585
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