Inhibition of Dynamin-Related Protein 1-Dependent Mitochondrial Fission Ameliorates Apical Periodontitis by Attenuating NLRP3 Inflammasome-Mediated M1 Macrophage Polarisation

Inhibition of Dynamin-Related Protein 1-Dependent Mitochondrial Fission Ameliorates Apical Periodontitis by Attenuating NLRP3 Inflammasome-Mediated M1 Macrophage Polarisation

Introduction and Aims: The aim of this study was to determine if Dynamin-related protein 1‌ (Drp1) -dependent mitochondrial fission is involved in the pathological process of apical periodontitis and elucidate the underlying mechanisms. Methods: Immunohistochemistry, immunofluorescence, and western...

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Main Authors: Yao Yang, Min Li, Lifei Pan, Yifei Tang, Yuting Wang, Xiaoyue Guan, Tiezhou Hou, Siyu Hou
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:International Dental Journal
Subjects:
Mitochondria dynamics
Apical periodontists
Mdivi-1
Macrophage
Dynamin-related protein 1
Online Access:http://www.sciencedirect.com/science/article/pii/S002065392500142X
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