Small molecule compound ZYZ-384 targets SMYD3 to alleviate aging

Small molecule compound ZYZ-384 targets SMYD3 to alleviate aging

Abstract SMYD3 is a chromatin modifier that facilitates the trimethylation of histone 3 lysine 4 (H3K4) to induce diverse biological activities. We have provided a brief demonstration of the anti-aging effect of ZYZ-384, a newly developed inhibitor targeting SMYD3. In order to validate the anti-sene...

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Bibliographic Details
Main Authors: Yang Liu, Dan Han, Li Jin, Xuena Xie, Huibo Li, Qian Ding, Yizhun Zhu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Chromatin modifier
Senescence
Cell proliferation
D-galactose
Online Access:https://doi.org/10.1038/s41598-025-10345-y
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https://doi.org/10.1038/s41598-025-10345-y

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