PD-1-dependent therapeutic effect of Trichinella spiralis cystatin on myocardial infarction in a mice model

PD-1-dependent therapeutic effect of Trichinella spiralis cystatin on myocardial infarction in a mice model

Abstract Background Ischemia-induced inflammation is the primary pathological mechanism underlying cardiac tissue injury caused by myocardial infarction (MI). Trichinella spiralis cystatin (Ts-Cys) has been shown to regulate macrophage polarization and alleviate various inflammatory and immune-relat...

Full description

Saved in:

Bibliographic Details
Main Authors:	Weixiao Zhang, Wenhui Yin, Hongtao Wang, Lingqin Wu, Chang Li, Xinyu Peng, Xiang Li, Kaibo Jiang, Huiqi Yang, Chenyue Dang, Erhe Gao, Qiwang Jin, Xiaodi Yang
Format:	Article
Language:	English
Published:	BMC 2025-06-01
Series:	Parasites & Vectors
Subjects:	Myocardial infarction Macrophage Trichinella spiralis PD-1 Inflammation Immunomodulation
Online Access:	https://doi.org/10.1186/s13071-025-06854-4
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Molecular and biological characterization of transforming growth factor-β homolog derived from Trichinella spiralis
by: Salisa Chaimon, et al.
Published: (2024-12-01)

Protective and therapeutic potentials of Trichinella spiralis larval antigen in murine induced colitis
by: Enas A. M. Huseein, et al.
Published: (2025-08-01)

Biological characteristics and functions of a novel glutamate dehydrogenase from Trichinella spiralis
by: Cheng Yong Kang, et al.
Published: (2024-01-01)

Occurrence of Trichinella spiralis in farmed wild boars (Sus scrofa): an underrated risk in China
by: Nian-Zhang Zhang, et al.

Efficacy of levamisole-loaded nanoparticles in the treatment of Trichinella spiralis infection in mice
by: F.A. Nasr, et al.
Published: (2025-07-01)

Steroid hormone binding and modulation of Trichinella spiralis progesterone receptor: A computational approach
by: Muhammad Tahir Aleem, et al.
Published: (2025-06-01)

The unique activity of the bone morphogenetic protein TGH4 affects the embryonic development of Trichinella spiralis and the establishment of vaccine protection
by: Wenjie Shi, et al.
Published: (2025-02-01)

Evaluation of karyopathic effects and general safety of <i>Trichinella spiralis</i> and <i>Echinococcus multilocularis</i> extracts in mice
by: E. I. Koveshnikova, et al.
Published: (2020-12-01)

Trichinella spiralis adult excretory-secretory antigen promotes peripheral regulatory T cell differentiation and attenuates experimental colitis via TGF-β-like mechanisms
by: Xi-Meng Sun, et al.
Published: (2025-07-01)

Trichinella spiralis-derived extracellular vesicles induce regulatory T cells and reduce airway allergy in mice
by: Sofija Glamočlija, et al.
Published: (2025-07-01)

First report of T. spiralis in a wolf in Italy: An increasing health concern?
by: G. Marucci, et al.
Published: (2025-03-01)

Effects of Trichinella spiralis excretory-secretory antigens on expression of indoleamine 2, 3-dioxygenase on dendritic cells in vitro
by: Yu Wenhao, et al.
Published: (2025-01-01)

Morphological and functional characteristics of Trichinella sp. larvae in bears and badgers in the Kirov Region
by: O. B. Zhdanova, et al.
Published: (2022-03-01)

Alendronate repositioning as potential anti-parasitic agent targeting Trichinella spiralis inorganic pyrophosphatase, in vitro supported molecular docking and molecular dynamics simulation study
by: Marmar A. Hanafy, et al.
Published: (2025-05-01)

MyD88 inhibitor TJ-M2010-5 alleviates spleen impairment and inflammation by inhibiting the PI3K/miR-136-5p/AKT3 pathway in the early infection of Trichinella spiralis
by: Huifang Bai, et al.
Published: (2025-02-01)

Viability of Trichinella spiralis in traditional sour pork fermentation and its inactivation by microwave heating: Implications for zoonotic risk and food safety
by: Atchara Artchayasawat, et al.
Published: (2025-06-01)

In Vitro Anthelmintic Effect of Mexican Plant Extracts and Partitions Against <i>Trichinella spiralis</i> and <i>Strongyloides venezuelensis</i>
by: Nancy E. Rodríguez-Garza, et al.
Published: (2024-12-01)

The effects of anti-lung cancer in nude mice by a fully human single-chain antibody against associated antigen Ts7TMR between A549 cells and Trichinella spiralis
by: Taotao Yue, et al.
Published: (2024-12-01)

miRNA let-7-5p present in the extracellular vesicles of Trichinella spiralis newborn larvae inhibits the function of M1-type RAW264.7 macrophages by targeting C/EBPδ
by: Yi Liu, et al.
Published: (2025-06-01)

Effects of <i>Trichinella spiralis</i> and <i>Echinococcus multilocularis</i> extracts after single and multiple injections on mitosis and hematological and biochemical parameters of mice
by: T. S. Novik, et al.
Published: (2023-01-01)

Anthelmintic efficiency of medicinal forms of albendazole received on mechanochemical technologies and use of address delivery Drug Delivery System on laboratory model
by: I. I. Glamazdin, et al.
Published: (2016-05-01)

Auditing of Danish pig herds for controlled housing requirements and Trichinella
by: Lis Alban, et al.
Published: (2024-12-01)

A paradigm shift in trichinellosis management: curcumin-olive oil nanocomposite’s multi-faceted therapeutic approach
by: Reem M. Ramadan, et al.
Published: (2025-05-01)

Study of Trichinella spp. Seroprevalence in Horse Population of West Azerbaijan, Northwestern Iran
by: Zanyar Pirkani, et al.
Published: (2025-02-01)

ENVIRONMENTAL AND PATHOGENETIC BASES OF FUNCTIONING OF PARASITIC SYSTEM FORMED BY TRICHINELLA (TRICHINELLA RAILLIET, 1895)
by: V. P. Tolokonnikov, et al.
Published: (2015-12-01)

Trichinosis is a topical health issue
by: S. B. Chuelov, et al.
Published: (2019-07-01)

Rosmarinus Officinalis L. essential oil: in Silico molecular docking and in vivo nematocidal activity on intestinal and muscular trichinellosis
by: Sara A. Abdel Salam, et al.
Published: (2025-07-01)

Genetic structure of Trichinella britovi populations in wildlife of north and northeast Iran
by: Faramarz Koohsar, et al.
Published: (2025-04-01)

First assessment of the prevalence of Trichinella in backyard-raised pigs in Central-Southern Chile
by: Javiera Guzmán-Faúndez, et al.
Published: (2025-12-01)

Beyond the known: Unraveling the existence of novel Trichinella genotypes (T14 and T15) in India and expanding the species complex
by: Rasmita Panda, et al.
Published: (2025-09-01)

Assessment of <i>Trichinella</i> Infection in Animals from Argentina
by: Fernando A. Fariña, et al.
Published: (2025-05-01)

Low prevalence of zoonotic food-borne parasites Toxoplasma gondii and Trichinella spp., but high prevalence of a potential marine Sarcocystis spp., in Eastern Beaufort Sea beluga whales (Delphinapterus leucas) harvested in the Canadian Arctic
by: Adrián Hernández-Ortiz, et al.
Published: (2025-01-01)

DIAMETER ARTERI SPIRALIS ENDOMETRIUM MENCIT BALB/C YANG DIBERI EKSTRAK KUNYIT ASAM (CURCUMA DOMESTICA DAN TAMARINDUS INDICA) SECARA ORAL DALAM PERIODE GESTASI DENGAN DOSIS BERTINGKAT
by: Nabella Jalinza Liyanda, et al.
Published: (2017-06-01)

Synthesis and In Vitro Biological Studies of Heterocyclic Benzimidazole Derivatives as Potential Therapeutics for Trichinellosis
by: Kameliya Anichina, et al.
Published: (2025-06-01)

STUDY OF THE DISTRIBUTION OF LARVAE IN MUSCLES AND SOME PERIPHERAL BLOOD PARAMETERS OF GALLUS GALLUS IN EXPERIMENTAL INFECTION WITH TRICHINELLA PSEUDOSPIRALIS
by: Olga B. Zhdanova, et al.
Published: (2024-08-01)

Proteomic analysis of the response of Trichinella spiralis muscle larvae to exogenous nitric oxide.
by: Xiaoli Wang, et al.
Published: (2018-01-01)

Ubiquitin-Dependent Modification of Skeletal Muscle by the Parasitic Nematode, Trichinella spiralis.
by: Rhiannon R White, et al.
Published: (2016-11-01)

Heterologous prime-boost immunization based on a human adenovirus 5 vectored containing Trichinella spiralis Cystatin-like protein elicits protective mucosal immunity in mice.
by: Nuo Xu, et al.
Published: (2025-07-01)

Controlled freezing inactivates Trichinella britovi in wild boar meat: Insights from a murine infection model and multiplex polymerase chain reaction
by: Olimpia C. Iacob, et al.
Published: (2025-06-01)

Pork Worm Trichinella spiralis (Paget, 1835) (Nematoda:Enoplea:Trichocephalida: Trichinellidae)
by: Daniel J. Freed, et al.
Published: (2022-06-01)