SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation

SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation

Abstract p14ARF is a lysine-less tumor suppressor that enhances SUMOylation of its interactors. Although p14ARF is known to interact with the E2 SUMO conjugating enzyme UBC9, the link between ARF and SUMOylation is poorly understood and the potential impact of SUMOylation on p14ARF is unknown. Here...

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Main Authors: Ahmed El Motiam, Yanis H. Bouzaher, Haifen Chen, Rocío Seoane, Santiago Vidal, María Blanquer, Rocío M. Tolosa, Beatriz Rodríguez-Lemus, José A. Herrera-Gavilán, Anxo Vidal, Ignacio Palmero, Manuel S. Rodríguez, James D. Sutherland, Rosa Barrio, Dimitris Xirodimas, Manuel Collado, Rod Bremner, Carmen Rivas
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07854-z
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https://doi.org/10.1038/s41419-025-07854-z

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