Env from EIAV vaccine delicately regulates NLRP3 activation via attenuating NLRP3-NEK7 interaction.

The current equine infectious anemia virus (EIAV) vaccine causes attenuation of the inflammatory response to an appropriate level, compared to that produced by virulent EIAV. However, how the EIAV vaccine finely regulates the inflammatory response remains unclear. Using a constructed NLRP3-IL-1β scr...

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Bibliographic Details
Main Authors: Xing Guo, Cong Liu, Yuhong Wang, Hongxin Li, Saiwen Ma, Lei Na, Huiling Ren, Yuezhi Lin, Xiaojun Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012772
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