High-fat diet impairs intermediate-term memory by autophagic-lysosomal dysfunction in Drosophila.

High-fat diet (HFD) is considered a risk factor for age-related memory impairments such as Alzheimer's disease. However, how HFD affects memory formation remains unclear. In this study, we established a model of memory defects caused by HFD in Drosophila. Our results revealed that the HFD impai...

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Bibliographic Details
Main Authors: Tong Yue, Minrui Jiang, Kotomi Onuki, Motoyuki Itoh, Ayako Tonoki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011818
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