Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion
5-Fluorouracil (5-FU) is a chemotherapeutic agent widely used in the treatment of gastrointestinal tract, skin and breast cancers. Hypersensitivity reactions may occur due to the use of chemotherapeutic drugs. The underlying mechanisms of hypersensitivity reactions to chemotherapeutic drugs are not...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2024-08-01
|
| Series: | Alergologia Polska |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Successful-desensitization-with-5-fluorouracil-in-a-patient-who-developed-anaphylaxis-after-5-fluorouracil-infusion,123,54602,1,1.html |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832584870044368896 |
|---|---|
| author | Mehmet Erdem Çakmak Nida Oztop Osman Ozan Yeğit |
| author_facet | Mehmet Erdem Çakmak Nida Oztop Osman Ozan Yeğit |
| author_sort | Mehmet Erdem Çakmak |
| collection | DOAJ |
| description | 5-Fluorouracil (5-FU) is a chemotherapeutic agent widely used in the treatment of gastrointestinal tract, skin and breast cancers. Hypersensitivity reactions may occur due to the use of chemotherapeutic drugs. The underlying mechanisms of hypersensitivity reactions to chemotherapeutic drugs are not clear and depend on the drugs. Hypersensitivity reactions may develop with both immunological and non-immunological mechanisms. 5-FU infusion chemotherapy may cause early types of life-threatening hypersensitivity reactions. If 5-FU infusion chemotherapy must be administered after an allergic reaction, it should be administered with a desensitization protocol. Life-threatening hypersensitivity reactions to 5-FU are rare in the literature. The case is here presented of a patient with metastatic gastric cancer who developed anaphylaxis during systemic 5-FU administration and was successfully desensitized to 5-FU. |
| format | Article |
| id | doaj-art-7b5ebfdbe8ca435ea9063f1db1a7314d |
| institution | Kabale University |
| issn | 2353-3854 2391-6052 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Alergologia Polska |
| spelling | doaj-art-7b5ebfdbe8ca435ea9063f1db1a7314d2025-01-27T10:35:04ZengTermedia Publishing HouseAlergologia Polska2353-38542391-60522024-08-0111433934110.5114/pja.2024.14214354602Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusionMehmet Erdem ÇakmakNida OztopOsman Ozan Yeğit5-Fluorouracil (5-FU) is a chemotherapeutic agent widely used in the treatment of gastrointestinal tract, skin and breast cancers. Hypersensitivity reactions may occur due to the use of chemotherapeutic drugs. The underlying mechanisms of hypersensitivity reactions to chemotherapeutic drugs are not clear and depend on the drugs. Hypersensitivity reactions may develop with both immunological and non-immunological mechanisms. 5-FU infusion chemotherapy may cause early types of life-threatening hypersensitivity reactions. If 5-FU infusion chemotherapy must be administered after an allergic reaction, it should be administered with a desensitization protocol. Life-threatening hypersensitivity reactions to 5-FU are rare in the literature. The case is here presented of a patient with metastatic gastric cancer who developed anaphylaxis during systemic 5-FU administration and was successfully desensitized to 5-FU.https://www.termedia.pl/Successful-desensitization-with-5-fluorouracil-in-a-patient-who-developed-anaphylaxis-after-5-fluorouracil-infusion,123,54602,1,1.html5-fluorouracil anaphylaxis drug allergy chemotherapy rapid desensitization |
| spellingShingle | Mehmet Erdem Çakmak Nida Oztop Osman Ozan Yeğit Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion Alergologia Polska 5-fluorouracil anaphylaxis drug allergy chemotherapy rapid desensitization |
| title | Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion |
| title_full | Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion |
| title_fullStr | Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion |
| title_full_unstemmed | Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion |
| title_short | Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion |
| title_sort | successful desensitization with 5 fluorouracil in a patient who developed anaphylaxis after 5 fluorouracil infusion |
| topic | 5-fluorouracil anaphylaxis drug allergy chemotherapy rapid desensitization |
| url | https://www.termedia.pl/Successful-desensitization-with-5-fluorouracil-in-a-patient-who-developed-anaphylaxis-after-5-fluorouracil-infusion,123,54602,1,1.html |
| work_keys_str_mv | AT mehmeterdemcakmak successfuldesensitizationwith5fluorouracilinapatientwhodevelopedanaphylaxisafter5fluorouracilinfusion AT nidaoztop successfuldesensitizationwith5fluorouracilinapatientwhodevelopedanaphylaxisafter5fluorouracilinfusion AT osmanozanyegit successfuldesensitizationwith5fluorouracilinapatientwhodevelopedanaphylaxisafter5fluorouracilinfusion |